Neurochemical effects of motor cortex stimulation in the periaqueductal gray during neuropathic pain
نویسندگان
چکیده
منابع مشابه
Motor cortex electric stimulation for the treatment of neuropathic pain.
OBJECTIVE Motor cortex stimulation (MCS) is considered to be an effective treatment for chronic neuropathic pain. The aim of the present study was to assess the efficacy of MCS for treating neuropathic pain. METHOD 27 patients with chronic neuropathic pain were operated. Electrodes were implanted with the use of an stereotactic frame. Electrophysiological evaluations (motor stimulation and so...
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Motor cortex stimulation (MCS) is relatively recent neurosurgical technique for pain control, the use of which is growing steadily since its description in the last decade. While clinical series show that at least 50% of patients with chronic, pharmacoresistant neuropathic pain may benefit from this technique, the mechanisms of action of MCS remain elusive. In this review, we synthesise a numbe...
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The idea that central pain syndromes can be treated by manipulation of the motor cortex derives from the landmark observations of Penfield (Lende et al., 1971). While reoperating on patients on whom he had previously resected a portion of the post central gyrus for epilepsy and whose seizures recurred, Penfield observed that stimulation of the corresponding primary motor cortex elicited sensory...
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Human neuroimaging offers a powerful way to connect animal and human research on emotion, with profound implications for psychological science. However, the gulf between animal and human studies remains a formidable obstacle: Human studies typically focus on the cortex and a few subcortical regions such as the amygdala, whereas deeper structures such as the brainstem periaqueductal gray (PAG) p...
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Motor cortex stimulation provides an alternate approach for intractable pain treatment. Optogenetic manipulation can produce gain- or loss-of-function in specific type of cells following light application. This state-of-the-art technology may be used in motor cortex stimulation to produce circuit-specific neuromodulation and regulate neuronal activities in motor cortex, thereby treating pain in...
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ژورنال
عنوان ژورنال: Journal of Neurosurgery
سال: 2020
ISSN: 0022-3085,1933-0693
DOI: 10.3171/2018.7.jns173239